Berberine is a bitter yellow plant alkaloid that has long been used in Chinese and Ayurvedic medicine. Berberine is found in several plants such as goldenseal and barberry. The medicinal use of Berberine goes back more than 3,000 years. Modern science has now identified precise mechanisms of action and given clear indications for the therapeutic benefits of berberine. Patients reported an increased tolerance for exercise, less fatigue, and less episodes of shortness of breath. There were also fewer deaths reported in the berberine group. Berberine supplementation appears to decrease cholesterol levels and reduces inflammatory markers.